Structure-function relationship of proteins by using genetic, biochemical,and physicochemical methods, mechanism of conformational switch and functional regulation induced by protein native strain, protein stability and folding, folding defects and cellular depense mechanism, funtional proteomics

1985~2000 Senior, Principal Research Scientist, KRIBB
2000~Present Principal Research Scientist, KIST
1997~2002 Director, Protein Strain Research Center, National Creative Research Initiatives, MOST
2002~Present Director, The Functional Proteomics Center, 21C Frontier R&D Program, MOST
1998~Present Regular Member, Asia-Pacific IMBN
2002~Present Regular Member, ASBMB
2002 Editorial in Chief, The Microbiological Society of Korea
2002 Chairman Scientific Advisory Committee, Korean Society for Biochemistry and Molecular Biology
1999~2001 National Focal Point, Regional Secretary of Gender,Science&Technology Asia&Pacific Rim, UNESCO
2001~2002 International Jury, L'OREAL Award

1995 The 5th Distinguished Publication Award/ Kor. Fed. of Science and Engineering Societies
1996 The 3rd Mokam Award/ Korean Society of Molecular Biology
1998 The 1st L'OREAL Award (Helena Rubinstein Award)/ UNESCO
2001 The 50th Seoul City Cultural Award/ Seoul City